Leonie Petitclerc1,2, Lydiane Hirschler1, Jack A. Wells3, David L. Thomas4,5,6, and Matthias J.P. van Osch1,2
1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands, 3UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, 4Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 5Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 6Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
In order to
measure the function of the blood-CSF barrier (BCSFB), a modified ASL
experiment is introduced. This is accomplished with multiple time-points, including
long labeling duration and post-labeling delay, and an echo train of 8 TEs from
10-1837ms. Long-T2 ASL signal, attributable to the CSF, was found
both in the choroid plexus and around the cortex. Fitting of this signal to two
models (a simple triexponential and a dynamic compartmental model) reveals an
amount of CSF signal about 5 times lower than the perfusion. The transfer time
of water across the BCSFB is estimated at around 100s.
