Abstract #0346

Ultra high-field, high-resolution, multi-voxel MRS in pre-manifest and early-manifest Huntington's Disease

Yan Li¹, Huawei Liu¹, Angela Jakary¹, Sivakami Avadiappan¹, Melanie Morrison¹, Ralph Noeske², Peder E.Z. Larson¹, Alexandra Nelson³, Katherine Possin³, Michael Geschwind³, Christopher Hess¹, and Janine M Lupo¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²GE Healthcare, Munich, Germany, ³Department of Neurology, University of California San Francisco, San Francisco, CA, United States

In this study of Huntington's Disease (HD), we evaluated brain metabolites from pre-manifest HD (PM) and early-manifest HD (EM), as well as their relationship to disease burden and motor disturbances. We used multi-voxel MRS at ultra-high field strength (7T), in order to improve the reliability and sensitivity of detecting focal metabolic changes that are related to HD. We found metabolic alterations in the thalamus and insula and changes in choline, mI, glutathione and glutamate that were correlated with clinical measures of disease severity.

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