A recently developed single-step spectral editing 1H MRS technique that induces intense Glu and Gln H4 singlets at TE = 56 ms was used to measure fractional enrichments of glutamate and glutamine in the dorsal anterior cingulate cortex (dACC) of five healthy volunteers after oral administration of [U-13C]glucose. This technique offers the ability to measure glutamate neurotransmission in the human brain with the high sensitivity and spatial resolution of 1H MRS using standard commercial equipment.
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