Abstract #0338

3D-CRT-FID-MRSI in the brain at 7T: Evaluation of regional concentration estimates

Gilbert Hangel^1,2, Benjamin Spurny³, Philipp Lazen², Cornelius Cadrien^1,2, Sukrit Sharma², Zoe Käfer², Nikolaus Doblinger², Lukas Hingerl², Eva Hečková², Bernhard Strasser², Stanislav Motyka², Alexandra Lipka², Stephan Gruber², Christoph Brandner⁴, Rupert Lanzenberger³, Karl Rössler¹, Siegfried Trattnig^2,5, and Wolfgang Bogner²

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria, ⁴High Field MR Centre, Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁵Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Applying a 3D-MRSI sequence with ~3 mm isotropic resolution and 15 min measurement time at 7T to a cohort of 24 healthy subjects, we successfully estimated the concentrations of 13 brain metabolites in 44 regions using internal water referencing. We established inter-subject coefficients of variation in the range of 10-20%. The resulting concentration estimates corresponded well to previous research except for GSH.

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