Abstract #0326

Associations in Alzheimer’s disease between Intracranial Vascular Metrics from 4D-Flow MRI and β-Amyloid and Tau PET

Leonardo A Rivera-Rivera^1,2, Karly A Cody¹, Tobey Betthauser¹, Robert V Cadman¹, Thomas Reher³, Howard A Rowley³, Cynthia M Carlsson¹, Laura Eisenmenger³, Sterling C Johnson¹, and Kevin M Johnson^2,3

¹Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

Cerebrovascular disease (CVD), has been linked with mild cognitive impairment and dementia stages of Alzheimer’s disease (AD); however, the question of whether CVD is associated with underlying AD pathophysiology remains unresolved. There remain many questions regarding CVD/AD pathophysiology interactions and whether related clinical AD dementia is enhanced by CVD. In this study, we investigated the relationship between cardiac and low frequency flow oscillations from 4D-Flow, white matter hyperintensities (WMHs) from T2 FLAIR MRI, and AD pathology assessed using β-amyloid (Aβ) and tau PET imaging data.

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