Perivascular spaces (PVS) are an important structural feature of the glymphatic system. PVS enlargement is associated with impaired glymphatic functionality and has been observed in both normative aging and neurodegenerative disorders; however, it is unclear how white matter PVS alterations affect neighboring cortical morphology in cognitively normal subjects. In the present study, we explore the relationship between PVS enlargement and cortical thickness across the normative lifespan. We found PVS enlargement preferentially influences cortical thickness of frontal regions, and this association is observed in children, adults and the elderly.
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