Abstract #0318

Repeatability of Liver Apparent Diffusion Coefficient Measurement Using Free-Breathing Diffusion-Weighted Propeller Echo-Planar Imaging

Hing-Chiu Chang¹, Lu Wang¹, Guangtao Chen¹, Liyuan Liang¹, Keith Wan-Hang Chiu¹, Yi-Jui Liu², Chun-Jung Juan^3,4,5, and Hsiao-Wen Chung^6,7

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ³Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, ⁴Department of Radiology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, ⁵Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan, ⁶Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ⁷Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

The current limitations of liver DWI mainly relate to the image quality and the repeatability/reproducibility of ADC measurement using single-shot DW echo-planar imaging (DW-EPI). The discrepancy of ADC measurement can substantially cause difficulty in cross-sectional or longitudinal liver DW-EPI. A preliminary study reported that a free-breathing liver DW-Propeller-EPI technique can provide superior image quality to conventional liver DW-EPI methods. In this study, we further improved the robustness of free-breathing liver DW-Propeller-EPI by incorporating velocity-compensation (VC) diffusion gradient into data acquisition, and then evaluated the repeatability of liver ADC measurement for free-breathing DW-Propeller-EPI by comparing to three routine liver DW-EPI methods.

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