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Abstract #0314

Macromolecular proton fraction mapping based on spin-lock for the non-invasive diagnosis of early stage liver fibrosis

Jian Hou1, Vincent Wai-Sun Wong2, Grace Lai-Hung Wong2, Baiyan Jiang1, Yi-Xiang Wang1, Anthony Wing-Hung Chan3, Winnie Chiu-Wing Chu1, and Weitian Chen1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 3Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Liver fibrosis is characterized by excessive accumulation of extracellular matrix proteins, such as collagen. Macromolecular Proton Fraction (MPF) is an indicator of the relative amount of macromolecular content. It was reported recently that MPF map can be obtained based on spin-lock (MPF-SL). In this work, we investigated the diagnostic value of MPF-SL for detecting early stage liver fibrosis on a clinical study.

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