Abstract #0287

Short-TE ECLIPSE for Macromolecular-Nulled MRSI in the Human Brain

Chathura Kumaragamage¹, Anastasia Coppoli¹, Peter B Brown¹, Scott McIntyre¹, Terence W Nixon¹, Henk M De Feyter¹, Graeme Mason¹, and Robin A de Graaf¹

¹Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States

An ECLIPSE-IVS based MRSI method was developed utilizing 3 ms GOIA-WURST RF pulses (BW = 15 kHz), operating at an RF amplitude B_1(95%) = 0.87 kHz. The ECLIPSE-IVS method was preceded with a water suppression module incorporating an optional inversion recovery (IR) component, to achieve macromolecule-nulled acquisitions. MRSI in vivo demonstrate robust extracranial lipid suppression with reliable, artifact-free metabolic maps generated with peak integration and LCModel fitting.

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