Abstract #0269

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate

Mahir Tazwar¹, Arnold M Evia Jr.², Ashish A Tamhane², David A Bennett², Julie A Schneider², and Konstantinos Arfanakis^1,2

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is now recognized as a common age-related neuropathology that has been linked to cognitive decline and dementia. In this work, the spatial pattern of R₂ alterations associated with LATE-NC was investigated in a large (N=797) community cohort of older adults. Voxel-wise analysis revealed a pattern of lower R₂ for greater LATE-NC burden, controlling for all other neuropathologies and demographics. This pattern involved mainly the temporal, frontal, occipital lobes and basal ganglia. To our knowledge this is the first R₂ investigation in LATE-NC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here