Age-related neuropathologies have devastating effects on subcortical brain structures. MRI can be used to explore patterns of atrophy associated with various diseases, however, definitive diagnosis of age-related neuropathologies is only possible at autopsy. Therefore, this work combined ex-vivo MRI and detailed pathologic assessment (gold standard) in a large (N=814) community cohort of older adults to investigate the link between age-related neuropathologies and the shape of different subcortical brain structures. The resulting patterns of deformation may contribute towards development or enhancement of in-vivo classifiers of these neuropathologies.
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