Abstract #0239

Quantitative sodium and diffusion imaging of mild traumatic brain injury: regional analysis findings

Anna M Chen¹, Teresa Gerhalter¹, Seena Dehkharghani^1,2, Rosemary Peralta¹, Fatemeh Adlparvar¹, James S Babb¹, Tamara Bushnik³, Jonathan M Silver⁴, Brian S Im³, Stephen P Wall⁵, Ryan Brown^1,6, Steven Baete^1,6, Ivan I Kirov^1,2,6, and Guillaume Madelin¹

¹Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, ⁵Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States, ⁶Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

27 mTBI patients and 19 controls were scanned at 3T. Total sodium concentration (TSC), fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured with voxel averaging in 12 grey and white matter regions-of-interest (ROIs). Patients had lower mean TSC than controls across all ROIs, however, statistical significance was only reached in the caudate. Statistically significant FA differences also occurred in only one region, frontal white matter (WM), while none were observed for ADC. TSC changes existed in mTBI and occurred with similar frequency as FA, but the FA finding had a higher effect size, and correlated with symptoms.

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