Abstract #0235

High-resolution 3D Phosphorus Metabolic Imaging of the Human Brain at 7T using SPICE

Hannes Michel Wiesner¹, Rong Guo^2,3, Yudu Li^2,3, Yibo Zhao^2,3, Zhi-Pei Liang^2,3, Xiao-Hong Zhu¹, and Wei Chen¹

¹CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Departments of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

In vivo ³¹P MRS imaging (MRSI) is unique to study brain energy metabolism including ATPase and creatine kinase metabolic rates, and the NAD redox ratio especially at ultrahigh field (UHF) with significant improvements in detection sensitivity and spectral resolution. Nevertheless it is still challenging to achieve high spatial resolution even at UHF, owing to extremely low concentration of phosphorus metabolites. In this study, we employed the subspace‐based image reconstruction method called SPICE to largely reduce spectral noise and increase the signal-to-noise ratio (SNR) for achieving high-resolution 3D ³¹P MRSI covering the entire human brain at 7T.

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