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Abstract #0218

Characterization of brain susceptibility changes in post-hospitalisation COVID-19 patients at 7 Tesla

Catarina Rua1,2, Christopher T Rodgers2,3, Virginia F J Newcombe2,4, Anne Manktelow4, Doris A Chatfield4, Stephen J Sawcer3, Joanne G Outtrim4, Victoria C Lupson2, Emmanuel A Stamatakis2,3,4, Guy B Williams2,3, William T Clarke5, Karen D Ersche6,7, Kyle Pattinson5, Edward T Bullmore6,7, David K Menon2,4,8, and James B Rowe1,9
1Department of Clinical Neurosciences and University of Cambridge Centre for Parkinson-plus, University of Cambridge, Cambridge, United Kingdom, 2Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 3Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 4Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, 5Welcome Centre for Integrative Neuroimaging (FMRIB), University of Oxford, Oxford, United Kingdom, 6Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, 7Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, 8on behalf of the Cambridge NeuroCOVID group (www.wbic.cam.ac.uk/neuro-covid/) and the CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge, United Kingdom, 9Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

Patients hospitalized with the new coronavirus disease (COVID-19) have shown severe changes in the central nervous system (CNS), particularly microhaemorrhages and encephalitis. However, long-term effects on the CNS haven not yet been fully characterised. In this study we scanned a group of 14 recently hospitalized COVID-19 patients at ultra-high field (7T) and analysed the microstructural changes measured by quantitative susceptibility mapping (QSM) from both subcortical nuclei and brainstem, which are thought to be targeted by the virus.

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