Infant cerebrospinal fluid dynamics assessed by low b-value diffusion tensor imaging and association with visible Virchow–Robin spaces

Cerebrospinal fluid (CSF) and interstitial fluid exchange via Virchow Robin space (VRS). It is reasonable to infer that VRS may be related to CSF dynamics. To investigate the association between CSF dynamics and VRS on infants, this work assessed CSF dynamics on infants by DTI with b values of 200 and 1000 s/mm² and segmented VRS on T2WI images. Results suggest that the ratio between diffusivities derived from low and high b-value DTI could provide complementary information for assessing infant cerebrospinal fluid dynamics. There may exist potential association between Virchow–Robin space volume and cerebrospinal fluid dynamics.