Abstract #0173

Optimized multi-axis spiral projection MRF with subspace reconstruction for rapid 1-mm isotropic whole-brain MRF in 2 minutes

Xiaozhi Cao^1,2, Congyu Liao^1,2, Siddharth Srinivasan Iyer^3,4, Gilad Liberman³, Zijing Dong^3,4, Ting Gong⁵, Zihan Zhou⁵, Hongjian He⁵, Jianhui Zhong^5,6, and Berkin Bilgic^3,7

¹Department of Rdiology, Stanford university, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford university, Stanford, CA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ⁵Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ⁶Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁷Department of Radiology, Harvard Medical School, Cambridge, MA, United States

To improve the quality and speed of 3D MRF, we applied spatiotemporal subspace reconstruction to 3D MRF and further modified its spiral-projection spatiotemporal encoding scheme. When compared to conventional sliding-window iNUFFT reconstruction, the subspace reconstruction provided markedly improved quantitative maps, with lower artifacts and higher SNR. The optimized spiral-projection encoding scheme, which was designed to increase spatiotemporal incoherency, was also validated to be more robust to artifacts, particularly at high accelerations. The proposed method enables high-quality whole-brain T₁, T₂, and proton density mapping with 1-mm isotropic resolution in 2 minutes and 0.8-mm isotropic resolution in ~4minutes.

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