Abstract #0133

Inductively coupled detectors for optogenetic-driven focal and multiregional fMRI signal enhancement

Yi Chen¹, Qi Wang^1,2, Hang Zeng^1,2, Kengo Takahashi^1,2, Sangcheon Choi^1,2, Chunqi Qian³, and Xin Yu^1,4

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, ³Department of Radiology, Michigan State University, East Lansing, MI, United States, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

To improve MR detection sensitivity of multi-modal fMRI platform, we present inductive coil which could relay locally detected MR signals to the external surface coil. Under sensory stimulation, evoked whole brain EPI-based fMRI and enhanced focal laminar-specific fMRI signals were acquired with high spatiotemporal resolution (100 μm and 100 ms) using a single experimental setup. Moreover, embedding inductive coil beneath the glue-secured optical fiber and the projection-mirrored cortex on the other hemisphere boosted multiregional fMRI sensitivity to investigate the interhemispheric connectivity with laminar-specificity. This is particularly helpful to study the optogenetic-driven brain connectivity with circuit specificity at multi-modal fMRI platform.

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