Abstract #0112

Combined spin echo and gradient echo slice-to-volume reconstruction in fetal diffusion MRI

Daan Christiaens^1,2, Maximilian Pietsch¹, Lucilio Cordero-Grande¹, Anthony N Price^1,3, Jana Hutter^1,3, Emer Hughes¹, Serena J Counsell¹, Joseph V Hajnal^1,3, and J-Donald Tournier^1,3

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department of Electrical Engineering (ESAT-PSI), KU Leuven, Leuven, Belgium, ³Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Modelling tissue microstructure during fetal and neonatal brain development relies on robustly sampling diverse, low-SNR image contrast in moving subjects. Here, we extend slice-to-volume reconstruction to multi-echo diffusion MRI, in order to correct subject motion across the combined diffusion-T₂*-weighted signal. Our results suggest that the spin echo and gradient echo dMRI signal have different trends across gestational age. Tissue microstructure models could therefore leverage these multidimensional data to reveal new insights in brain development.

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