Advanced non-invasive functional imaging methods have been widely used, but with certain limitations in either temporal or spatial information. There has long been a demand for a noninvasive imaging method capable of capturing neuronal activity with high temporal and spatial resolution. Here, we demonstrate a novel imaging method (called DIANA-fMRI) for directly detecting neuronal activity with high temporal (=5ms) and spatial (=0.22mm) resolution. DIANA-fMRI was capable of capturing sensory responses in mice at 9.4T with statistically significant signal changes (~0.1-0.2%). Temporally sequential DIANA responses were also confirmed along the thalamocortical pathway, together with further validation by electrophysiological experiments.
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