Abstract #0083

Comparison of inhomogeneous Magnetization Transfer (ihMT), R1 and MPF for myelin specific imaging

Andreea Hertanu^1,2, Lucas Soustelle^1,2, Arnaud Le Troter^1,2, Julie Buron^1,2,3, Julie Le Priellec³, Myriam Cayre³, Pascale Durbec³, Gopal Varma⁴, David C. Alsop⁴, Olivier M. Girard^1,2, and Guillaume Duhamel^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Aix Marseille Univ, CNRS, IBDM, Marseille, France, ⁴Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

We conducted a comparative study of ihMT metrics variably weighted in T_1D, with R₁ (1/T₁) and MPF (macromolecular proton fraction) for myelin specific imaging. These MRI methods were compared with histology by fluorescence microscopy using transgenic plp-GFP (proteolipid protein-Green Fluorescent Protein) mice.

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