Spatiotemporal encoding (SPEN) is an alternative ultrafast imaging technique which allows to overcome distortions otherwise observed along EPI’s phase-encoded dimension, and to perform self-referenced phase corrections in interleaved diffusion weighted imaging (DWI) scans. This study compares SPEN’s performance against multishot read-out segmented EPI (RESOLVE), with an emphasis on high-b-valued DWI and diffusion kurtosis imaging in the context of breast cancer imaging. The results show SPEN’s advantages for delivering kurtosis maps that provide a separation between cancerous and healthy tissues. The potential of using SPEN DW images acquired with high b-values as an alternative to DCE subtractions is also assessed.
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