Abstract #4854

Validation of USPIO-MRI for detection of lymph node metastases in head and neck cancer: feasibility and workflow.

Daphne A.J.J. Driessen¹, Tim Dijkema¹, Sjoert A.H. Pegge², Patrik Zámecnik², Adriana C.H. van Engen-van Grunsven³, Willem L.J. Weijs⁴, Robert P. Takes⁵, Tom W.J. Scheenen², and Johannes H.A.M. Kaanders¹

¹Radiation Oncology, Radboud university medical centre, Nijmegen, Netherlands, ²Radiology and Nuclear Medicine, Radboud university medical centre, Nijmegen, Netherlands, ³Pathology, Radboud university medical centre, Nijmegen, Netherlands, ⁴Oral- and Maxillofacial Surgery and Head and Neck Surgery, Radboud university medical centre, Nijmegen, Netherlands, ⁵Otorhinolaryngology and Head and Neck Surgery, Radboud university medical centre, Nijmegen, Netherlands

Head and neck cancers have a high propensity to metastasize to the lymph nodes of the neck. Accurate knowledge of this regional nodal status is of great importance for therapy selection and prognosis. Ultrasmall superparamagnetic iron oxide (USPIO) particles (Ferumoxtran-10 / Ferrotran®) are a promising contrast agent that can be used to detect nodal metastases with MRI. This study aims to validate USPIO-MRI for the detection of nodal metastases in head and neck cancer patients with histopathology as the reference standard. The workflow and preliminary results in 5 patients are shown in this abstract.

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