Abstract #4846

Prediction of Treatment Outcome after Radiosurgery in Brain Metastases from Lung Cancer Using Preradiosurgical MR Radiomics

Chien-Yi Liao¹, Cheng-Chia Lee^2,3,4, Huai-Che Yang^2,3, Wen-Yuh Chung^2,3, Hsiu-Mei Wu^3,5, Wan-Yuo Guo^3,5, Ren-Shyan Liu^1,6, and Chia-Feng Lu^1,7

¹Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ²Department of Neurosurgery, Neurological Institute, Taipei Veteran General Hospital, Taipei, Taiwan, ³School of Medicine, National Yang-Ming University, Taipei, Taiwan, ⁴Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ⁵Department of Radiology, Taipei Veteran General Hospital, Taipei, Taiwan, ⁶Department of Nuclear Medicine and National PET/Cyclotron Center, Taipei Veterans General Hospital, Taipei, Taiwan, ⁷Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan

The development of brain metastases is a devastating consequence of disease progression of advanced non-small cell lung cancer patients. This study proposed an approach to predict the treatment outcome after gamma knife radiosurgery based on preradiosurgical MR radiomics. We suggested that imaging characteristics extracted from preradiosurgical MRIs can be potential image biomarkers for the outcome prediction.

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