Preclinical evidence points towards a metabolic reprogramming in isocitrate dehydrogenase mutated tumor cells with downregulation of the expression of genes that encode for glycolytic metabolism. We non-invasively investigated lactate concentrations, as well as intracellular pH using 1H and 31P MRS in a glioma patient cohort. At TE 97 ms, lactate peaks can be fitted with little impact of lipid/macromolecule contamination. We found a significant difference in lactate concentrations and intracellular pH comparing tumor voxels of IDH mutatet to IDH wildtype patients, with reduced lactate levels and near normal intracellular pH in IDHmut patients.
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