SSIFT is a recently developed MRI method that provides a specific means to detect brain tumors based on their differences in cell size. However, to date SSIFT has not been adequately validated. We therefore used computer simulations and studies of cultured cells in vitro and animal models in vivo to comprehensively validate SSIFT for brain cancer imaging. The results suggest SSIFT is highly specific for cell size and can differentiate brain tumors from other brain abnormalities such as peri-tumor edema and radiation necrosis, which cannot be reliably distinguished by other current MRI methods.
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