Diffusion MRI is sensitive to the configuration of cell structures on the microscopic level, and may be a biomarker of tumor grade. High-grade gliomas are hypothesized to be more heterogeneous on a microscopic scale, when compared to low-grade; a feature that should be reflected in the diffusional kurtosis. To explore this premise, we use tensor-valued diffusion encoding to disentangle the isotropic and anisotropic kurtosis and relate them to tumor grade and tumor tissue that is enhancing vs. non-enhancing on post-gadolinium T1 maps.
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