Repeatability of quantitative imaging metrics is important for establishing precision of diagnostic and prognostic measurements. In the multi-center ACRIN6698 trial, mean apparent diffusion coefficient (ADC) of breast tumors showed excellent repeatability but only moderate predictive power for breast cancer therapy response. Previous single-center studies have shown improved predictive performance using alternative ADC histogram metrics related to dense tumor volume. This study evaluates repeatability for a variety of alternative ADC histogram metrics to establish confidence intervals and inform predictive models for future breast cancer therapy response analysis.
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