Abstract #4754

Hypoxia alters normal fibroblast metabolism towards a cancer associated fibroblast phenotype

Jesus Pacheco-Torres¹, Tariq Shah¹, William Nathaniel Brennen², Flonne Wildes¹, and Zaver M Bhujwalla^1,2,3

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Fibroblasts play a pivotal role in cancer progression. In prostate cancer, fibroblasts have been shown to induce growth, confer castration-resistance, and increase metastatic potential. To further understand how fibroblasts respond to hypoxic tumor microenvironments that are frequently observed in prostate cancer, here we have characterized the effects of hypoxia on normal prostate fibroblast metabolites as detected by high resolution ¹H magnetic resonance spectroscopy. We found that hypoxia induced metabolic changes in normal prostate fibroblasts that mimicked the metabolites detected in prostate cancer associated fibroblasts (CAFs), highlighting the potential role of hypoxia in the transition of normal fibroblasts to CAFs.

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