In this study, we verified the feasibility of apparent diffusion coefficient (ADC) values in predicting chemotherapy response and optimizing chemotherapy regimen for gastric cancer that is resistant 5-FU with mouse model. We found that based on the early changes of ADC to replace 5-FU with paclitaxel in advance can effectively reduce tumor burden which means it may be possible to use ADC values as a reliable bio-marker in predicting chemotherapy response and optimizing chemotherapy regimen for gastric cancer.
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