Abstract #4724

Brain and plasma choline compounds altered by cancer and cancer-induced cachexia

Santosh K Bharti¹, Paul T Winnard¹, Raj Kumar Sharma¹, Marie-France Penet^1,2, Balaji Krishnamachary¹, and Zaver M. Bhujwalla^1,2,3

¹Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine,, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³3Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cancer induced cachexia is a multifactorial syndrome that results in unexplained weight loss in cancer patients. A major cause of morbidity and mortality, the syndrome is most prevalent in pancreatic cancer. Here we have identified changes in brain choline metabolites and plasma choline in human pancreatic cancer xenografts that induce cachexia (Pa04C) as well as noncachexia inducing pancreatic cancer xenografts (Panc1), compared to normal mice. These results highlight the systemic changes in choline metabolism that occur with cancer and with cancer induced cachexia that may lead to the development of early biomarkers as well to metabolic treatment strategies.

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