Abstract #4717

Microstructures and metabolites during HIV-1 infection of humanized microglia mice revealed by MRI and MRS

YUTONG LIU¹, Saumi Mathews², Ed Makarov², Lili Guo², Mariano Uberti¹, Balasrinivasa Sajja¹, Larisa Poluektova², Howard Gendelman², and Santhi Gorantla²

¹Radiology, University of Nebraska Medical Center, Omaha, NE 68198, NE, United States, ²Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, NE, United States

In this study, we performed DTI and MRS on a newly created mouse model of brain HIV infection. MRS results showed neuronal damage on hippocampus, and DTI showed diffuse neuroinflammation caused by HIV infection. White matter changes was also observed using DTI.

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