Abstract #4711

Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains

Azadeh Nazemorroaya¹, Ali Aghaeifar¹, Hildegard Schulz¹, Thomas Shiozawa-Bayer², Bernhard Hirt², Klaus Scheffler^3,4, and Gisela Hagberg^4,5

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Clinical Anatomy, University of Tübingen, Tuebingen, Germany, ³High Field Magnetic Resonance,, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Biomedical Magnetic Resonance, University of Tübingen, Tuebingen, Germany, ⁵High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Post-mortem brain MRI can yield valuable information. However, tissue preservation and MR-compatibility of fixation agents are challenging. Here we investigated the effect of four MR-compatible formalin-based fixatives on the MR properties of pig brains at several timepoints after start of fixation up to one month. The inclusion agents known to improve the dielectric properties of the fixatives lead to greater R₂^* difference between GM-WM than conventional fixatives. Vice versa these agents lead to a decrease in T₁ contrast.

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