Abstract #4681

Characterization of brain metabolite changes in early childhood

Ashley D Harris^1,2, Tiffany Bell^1,2, Mercedes Bagshawe^1,2, Elodie Boudes^1,2, and Catherine Lebel^1,2

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Alberta Children's Hospital Research Institute and the Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Using proton MRS, we examine longitudinal changes in tNAA, tCr, tCho, Ins and Glx in early childhood in a typically developing children ages 2.4-9.3 years. We show NAA increases in the anterior cingulate across both sexes while age-relate changes in NAA in the left angular gyrus are only seen in boys. In the anterior cingulate tCr in girls increases and tCho decreases in boys. By contrast in the left angular gyrus tCr increases in boys and tCho decreases in girls. These different metabolite trajectories in different brain regions may be associated with different development seen between boys and girls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here