Abstract #4679

Pediatric acute mTBI study of GABA concentration in posterior cingulate cortex

Andrei Manzhurtsev^1,2, Maxim Ublinskiy^1,3, Petr Menshchikov¹, Alexey Yakovlev^2,4, Olga Bozhko³, Tolib Akhadov³, and Natalia Semenova^1,3,4

¹Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, ²Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russian Federation, ³Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, ⁴Semenov Institute of Chemical Physics of the Russian Academy of Science, Moscow, Russian Federation

This is the first measurement of pure GABA concentration in the PCC of children with mild TBI in the acute phase. MEGA-PRESS pulse sequence was used in order to obtain GABA signal not contaminated by macromolecules. The result obtained disagrees with the previous study, where [GABA] was increased in the anterior cingulate cortex of children with mTBI when comparing to healthy controls. The findings may signify that ACC is more sensitive to mTBI than PCC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here