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Abstract #4661

Low Frequency Fluctuations in White Matter of Perinatally HIV-Infected Adult Youths: Glial Cycling for Neuroplasticity and Repair?

Manoj Kumar Sarma1, Amrita Pal2, Margaret A. Keller3,4, Tamara Welikson5, Joseph Ventura6, David E. Michalik7, Karin Nielsen-Saines8, Jaime Deville8, Andrea Kovacs9, Eva Operskalski9, Joseph A. Church9,10, Irwin Walot11, Paul M. Macey2, Bharat Biswal12, and M. Albert Thomas1
1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2UCLA School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States, 4The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States, 5Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 6Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 7Infectious Diseases-Pediatrics, Miller Children’s Hospital of Long Beach, Long Beach, CA, United States, 8Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 9Pediatric, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States, 10Children’s Hospital Los Angeles, Los Angeles, CA, United States, 11Radiology, Los Angeles County Harbor- UCLA Medical Center, Torrance, CA, United States, 12Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States

We evaluated the functional brain activity in perinatally HIV-infected youth (PHIVY) on cART by quantifying the amplitude of low frequency fluctuations (ALFF) and correlated with clinical and cognitive measures. We observed higher neural activity for ALFF in PHIVY compared to control. ALFF values in the cerebral white matter were positively correlated with viral load. Higher neural activity was associated with poorer performance in psychomotor function, abstract thinking, and social cognition. The findings suggest that long-term consequence of higher neuroinflammation and associated neurorepair in PHIVY may have a significant impact on regional spontaneous neuronal firing consequently impacting neurodevelopment and cognitive functioning.

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