Developmental milestones are essential for a child’s development, with early milestones building a stepping-stone for more complex skills later. In this study, we investigate resting state functional connectivity (fc) before and after major developmental milestones (walking, pincer grasp, first words) were reached in a large cohort of typically developing children (3 to 30 months). Reaching a milestone showed a different fc pattern across all skill domains. Opposite to more complex skills where fc strengthened with skill advancement, walking recruited fewer fc networks when the milestone was reached, possibly underlining the importance of automaticity and complexity demand for the milestone achieved.
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