Abstract #4626

Simultaneous micro- and macrostructural assessment of normal brain development

Bénédicte Maréchal^1,2,3, Gian Franco Piredda^1,2,3, Tom Hilbert^1,2,3, Clovis Tauber⁴, Jean-Philippe Cottier⁴, Jean-Philippe Thiran³, Tobias Kober^1,2,3, and Baptiste Morel^4,5

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴UMR 1253, iBrain, Université de Tours, Inserm, Tours, France, ⁵Pediatric Radiology Department, Clocheville Hospital, CHRU of Tours, Tours, France

MRI has become a routine diagnostic modality for evaluating normal structural and metabolic development of the brain in children. In this work, MP2RAGE sequence parameters and consecutive automated brain morphometry are optimized to overcome cohort-specific challenges due to wide variations in head size, head shape, and rapid changes in tissue contrast associated with myelination. Reference ranges for both volumetric and T₁-relaxometry measures are built from a pediatric population with normal MRI findings. We also provide an initial assessment of potential clinical applications of these micro- and macrostructural features and corresponding normative ranges using selected cases with abnormal findings.

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