Abstract #4612

Decreased fractional anisotropy in the diffusion tensor imaging of neonatal hypoxic ischemic encephalopathy with normal conventional MRI

Qiang Zheng¹, Chenying Zhao², Minhui Ouyang³, Arastoo Vossough⁴, Giulio Zuccoli³, Raymond Wang Sze⁴, Hao Huang⁴, and Misun Hwang⁴

¹School of Computer and Control Engineering, Yantai University, Yantai, China, ²University of Pennsylvania, Philadelphia, PA, United States, ³Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ⁴Children’s Hospital of Philadelphia; University of Pennsylvania, Philadelphia, PA, United States

Diffusion tensor imaging (DTI) plays an important role in the diagnosis and prognosis of neonatal hypoxic ischemic encephalopathy (HIE). However, studies on DTI in HIE neonates with normal DWI, T1/T2-weighted images (referred as conventional MRI) are rarely reported. Here, we compared fractional anisotropy (FA), mean diffusivity, radial diffusivity, axial diffusivity among controls, HIE neonates with normal conventional MRI, and HIE neonates with abnormal conventional MRI. The results demonstrate that FA is the most sensitive DTI measurement, and significantly decreased in HIE neonates with normal MRI, suggesting the importance of inclusion of DTI for evaluating HIE in clinical practice and research.

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