Abstract #4607

Brain oxygen extraction fraction is associated with 10minute Apgar score and severity of hypoxic ischemic encephalopathy

Dengrong Jiang¹, W. Christopher Golden², Charlamaine Parkinson², Li Pan³, Zixuan Lin¹, Hanzhang Lu¹, Aylin Tekes¹, Frances Northington², and Peiying Liu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Siemens Healthineers, Baltimore, MD, United States

Hypoxic-ischemic-encephalopathy (HIE) is a leading cause of neonatal mortality and severe neurological impairment in childhood. Quantification of cerebral oxygen utilization in HIE neonates may provide valuable information to guide the treatment and predict clinical outcomes. Oxygen-extraction-fraction (OEF) is an important index of the brain’s oxygen utilization. In this work, we used a rapid, non-invasive MRI technique to measure the global OEF in HIE neonates, and examined the association of OEF with Apgar scores and the severity of HIE. We demonstrated that global OEF was associated with 10minute Apgar score. Global OEF also decreased with the severity of HIE.

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