Abstract #4592

Investigation of Longitudinal Nonhuman Primate White Matter Maturation using Quantitative R1 Relaxometry

Douglas C Dean^1,2,3, Jason F Moody², Steve R Kecskemeti³, Nakul Aggarwal⁴, Jonathan A Oler⁴, Andrew L Alexander^2,3,4, and Ned Kalin⁴

¹Pediatrics, University of Wisconsin–Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin–Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin–Madison, Madison, WI, United States, ⁴Psychiatry, University of Wisconsin–Madison, Madison, WI, United States

Quantitative relaxometry affords a unique opportunity to map dynamic patterns of white matter development. Nonhuman primates offer a valuable model for investigating neurodevelopment, however, NHP studies utilizing relaxometry based approaches have been limited. Here, we utilize R₁ relaxometry to map maturation in 35 rhesus macaques scanned across 5 timepoints during the first year of life. R₁ is observed to rapidly increase during this period, with average and individual patterns exhibiting a logarithmic-like trajectory. Results highlight the onset of myelin during this period of development and demonstrate relaxometry to be a promising approach for characterizing patterns of early brain development.

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