Abstract #4563

Two-step approach in IVIM parameter quantification

Xin Li¹, Ryan Kopp^2,3, William D Rooney¹, Fergus Coakley⁴, and Mark Garzotto^2,3

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Portland VA Medical Center, Portland, OR, United States, ³Urology, Oregon Health & Science University, Portland, OR, United States, ⁴Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States

The goal of this study is to investigate a new two-step approach in intra-voxel incoherent motion (IVIM) imaging data quantification. This methods first determines the slow diffusion constant (D) then the pseudo-perfusion parameters (D*, f) using the IVIM model fitting but holding D at pre-determined value. Results show that the new approach returns more consistency parametric maps and the new modeling is favored by Akaike information criterion (AIC).

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