Oxygen molecule is paramagnetic and its relaxation-time-shortening effect is strongly enhanced in viscous intracellular environment following the BPP theory. Therefore, DWI signal, which enhances intercellular signal, could reflect oxygen concentration changes in the cell. To verify this property, we formulated an equation of MR signal that includes signal increase/decrease by T1/T2 shortening by oxygen; there exists a TE (TE0) at which the relaxation-time-shortening effect counterbalances showing no signal change. We obtained successive DWI signal of brain under resting-state, and observed the existence of TE0 supporting that intracellular oxygen concentration changes are visible in DWI signal.
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