Abstract #4551

A DTI Comparative study – Is demyelination in AD resembling primary demyelinating disease (MS) or secondary demyelinating disease (NPSLE)?

Huiqin Zhang¹, Hui Zhang¹, Franki Kai-Hei Tse ², Edward Sai-Kam Hui¹, Peng Cao¹, Kannie Wai Yan Chan³, Queenie Chan⁴, Karl HERRUP⁵, and Henry Ka Fung Mak¹

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong, ³Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ⁴Philips Healthcare, Hong Kong, Hong Kong, ⁵Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States

Demyelination is a known pathology in AD, but it is unclear whether such myelin loss resembles primary or secondary demyelinating disease. Here, we retrospectively analysed the DTI data using voxel-wise TBSS analysis and made pair-wise comparisons between cohorts of AD, Relapsing-remitting MS(RRMS), NPSLE and normal controls (NC). In diffusion metrics analysis, widespread microstructural patterns were similarly found between AD and MS in terms of diffusion metrics, but not between AD and NPSLE. Our results indicate that the microstructural WM changes in AD may share similar pathological mechanisms in demyelinating disease of RRMS.

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