Abstract #4539

Preliminary Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer’s Disease

Maurizio Bergamino¹, Ashley Nespodzany¹, Leslie C Baxter^1,2, Anna Burke³, Richard Caselli², Marwan N Sabbagh⁴, Ryan R Walsh⁵, and Ashley M Stokes¹

¹Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²Mayo Clinic Arizona, Phoenix, AZ, United States, ³Department of Neuropsychiatry, Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, ⁵The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States

The objective of this study was to assess complementary metrics from voxel-based morphometry (VBM) and intravoxel incoherent motion diffusion-weighted images (IVIM-DWI) MRI methods in aging populations. Using voxel-based analysis, grey matter (GM) and white matter (WM) differences were analyzed across Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively normal (HC) individuals. IVIM-DWI demonstrated early significant differences between MCI and HC groups, while VBM did not. In addition, voxel-based correlations between neuroimaging metrics and cognitive assessments were assessed in the cognitively impaired groups (AD and MCI).

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