Electro-mechanical models of heart function rely upon accurate representation of microstructural orientations in the myocardium. We assessed the sensitivity of a finite element parameterisation of the myofibre orientation field derived from high-resolution DWI data of a canine heart. Eigenanalysis of the indifference region in the neighbourhood of the optimal fit of the myofibre field enabled quantification of helix angle uncertainty consistent with the DWI data. This method can be used to propagate the uncertainty in myofibre parameterisation to electro-mechanics simulation results.
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