Fundamental Cell Biology Properties Underlying In Vivo DWI

With cellular ensembles featuring stochastic [“Voronoi”] geometries, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to cell biology parameters measuring membrane Na⁺,K⁺‑ATPase [NKA] activity, cell density, ρ, and voxel average cell volume, <V>. Furthermore, the simulations matching disparate in vivo tissue [murine xenograft colorectal cancer, human cerebral cortex, and human bladder] experimental b‑space decays have parameters [cellular water efflux rate constant <k_io>, ρ, and <V>] in near absolute agreement with the most pertinent literature. Inspecting the common, empirical early decay measure, ADC, of these simulations provides insights into acute and chronic tissue property changes in vivo.