Abstract #4496

Water diffusion pore imaging on a 14.1 T spectrometer using glass capillary phantoms in the presence of extraporal fluid

Dominik Ludwig^1,2, Frederik Bernd Laun³, Karel D. Klika⁴, Mark Edward Ladd^1,2,5, Peter Bachert^1,2, and Tristan Anselm Kuder¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Diffusion pore imaging (DPI) can be used to retrieve the pore space function of arbitrary closed pores. In this study we show that DPI of glass capillaries is possible even under difficult experimental conditions. By separating the long gradient into a CPMG-like gradient echo train and matching the magnetic susceptibility, it was possible to acquire diffraction patterns of glass capillaries that were placed orthogonal to the main magnetic field. Furthermore, the feasibility of doing DPI in the presence of water outside the pores was demonstrated for the first time.

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