Diffusion modelling of the time dependence of the skeletal muscle diffusion eigenvalues derived from DTI allows one to probe tissue microstructure. We applied the Random Permeable Barrier Model to the time dependent diffusion data to identify age related remodeling in skeletal muscle microstructure. Model derived volume fraction (measure of the membrane’s ability to hinder diffusion) decreased with age while diffusion time and residence time in a cell increased with age while other model parameters such as the free diffusion coefficient, the fiber size, and membrane permeability did not.
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