Abstract #4411

Spatiotemporal evolution of ischemic lesions in stroke animal models using free-water elimination and mapping with explicit T2 modelling

Ezequiel Farrher¹, Chia-Wen Chiang², Kuan-Hung Cho², Richard Buschbeck¹, Ming-Jye Chen², Zaheer Abbas¹, Kuo-Jen Wu³, Yun Wang³, Farida Grinberg¹, Chang-Hoon Choi¹, N. Jon Shah^1,4,5,6, and Li-Wei Kuo^2,7

¹INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ³Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan, ⁴Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁵JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, ⁶Institute of Neuroscience and Medicine 11, JARA, Forschungszentrum Jülich, Jülich, Germany, ⁷Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

It is known that excess fluid as a result of vasogenic oedema formation following stroke onset obscures the microstructural characterisation of ischemic tissue by diffusion MRI. DTI-based free water elimination and mapping (FWE) has been proposed as a technique to potentially reduce the partial-volume effect. However, FWE estimation is ill-conditioned, leading to inaccurate results. More recently, it has been shown that the addition of a second dimension spanned by transverse relaxation weighting, mitigates the ill-conditioned problem. We aim here to investigate the latter model in a longitudinal study of MCAo stroke animal models.

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