Erick O Buko1, Afis Ajala1, Jiming Zhang2, and Pei Herng Hor1
1Physics, Texas Center for Superconductivity at University of Houston, Houston, TX, United States, 2Diagnostic and Interventional Radiology, Baylor St. Luke's Medical Center, Houston, TX, United States
We present a simple phantom set-up to model
diffusion weighted imaging signal arising from intra-voxel incoherent motion
(IVIM). The model provides means to
independently control both the perfusion fraction (f) as well as the pseudodiffusion coefficient (Df). Across a
range of flow velocities, numerical simulations and phantom experiments confirm
that: (a) perfusion fraction (f) is
overestimated by traditional analysis approaches such as segmented (S), or
oversegmented (OS) methods, but is slightly underestimated by the AS-T2 method;
(b) Df increases in
proportion to flow velocity, and the estimation of Df is unaffected by the analysis technique.
